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Neonatal screening or Newborn Screening involves the screening of newborns in the first days of their lives for inborn errors of metabolism and certain disorders that can hinder the normal development of the baby. These disorders, are not apparent at the time of the baby's birth, but have potential to cause permanent neurological, cognitive, tactile and physical damage in the child. Early detection of such diseases enable initiating of suitable interventions to prevent concerning conditions in the long run. Trivitron provides a wide range Newborn Screening instruments, including Modular & Fully Automated NBS Instrumentation, manual & automated equipment and reagent kits. Trivitron's Diagnostic division Labsystems Diagnostics OY occupies the second place in the world when it comes to New Born Screening Technology.
Fluoro Enzymatic Assays
Labsystems Diagnostics is the first company in the world to introduce fluorometric microplate based assay for phenylalanine for diagnosing phenylketonuria (PKU) in newborns. Its pioneered Newborn Screening products and systems are based on fluorescence and photometric detections. All the reagent kits can be used manually in modular systems or in fully automated and hands off systems.
To run a successful and cost-effective newborn screening test, there is a requirement for all the instruments and reagents. Trivitron's Labsystems Diagnostics Oy delivers the most sophisticated fully-automated solutions in the highest quality and performance standards, ensuring the highest levels of performance for your lab.
Labsystems Diagnostics introduced world's first fluorometric microplate based assay for screening Phenyl Alanine in newborns to detect Phenylketonuria (PKU) and now on tandem MS along with more than 50 disorders. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) increased the screening possibilities by monitoring levels of amino acids and acylacarnitines. These tests can also be used in screening positive samples as a second tier confirmation test to differentiate between true and false positive samples. LC-MS/MS can detect several disorders with a single injection, which is important in high throughput labs.
Triviton’s Newborn Screening is based on chemical enzyme assay and monoclonal antibody-based enzyme immunoassay using a microtitre plate, photometry technology has been proved effective in case finding and offers a number of advantages. Reduced labour componentEase of handlingUse of nonradioactive reagentsLong reagent shelf-lifeBetter specificityReduction in potential sample handling and transposition errors These features combine to make this technology appropriate for a large to medium-volume neonatal screening laboratory.Newborn Screening Assays from Dried Blood Spots (DBS)Kits include- NeoScreen TSH, NeoScreen 17OHP, NeoScreen G6PD, NeoScreen Galactose, NeoScreen IRT
Early detection and screening of SCID-SMA is a vital health goal for infants
